Last week during a poster session in the Department of Statistics, I had an interesting discussing with Martin Buttenschoen (working on the other side of the group) regarding the difference between small molecules and antibodies as therapeutics. This discussion made me realise that even though I’m working on antibodies engineering and developability, I could use a little refresher on approved therapeutic antibodies and their mechanisms of action. 

In case you also need this bigger picture, or want to get excited about therapeutic antibodies yourself, I will summarise the target, the development process, the molecular function, and the administration for three successful therapeutic antibodies.