Nanobodies are an exciting area of increasing interest in the biotherapeutics domain. They consist only of a heavy chain variable domain so are much smaller than conventional antibodies (about 1/10th of their mass) but despite this, manage to achieve comparable affinity for their targets, in addition to being more soluble and stable – good things come in small packages! Nanobodies are not naturally produced in humans but can be derived from camelids (VHHs) or sharks (vNARs) and then engineered to humanise them. For the rest of this blog post we will skip over the science entirely and learn how to draw a llama, a great example of a camelid species.
Category Archives: Humour
Musings on Digital Nomaddery from Seoul
The languorous, muggy heat of the Korean afternoon sun was what greeted me after 13 hour cattle-class flight from a cool, sensible Helsinki night. The goings-on in Ukraine, and associated political turmoil, meant taking the scenic route – avoiding Russia and instead passing over Turkey, Kazakstan and Mongolia – with legs contorted into unnatural positions and sleep an unattainable dream. Tired and disoriented, I relied less on Anna’s expert knowledge of the Korean language than her patience for my jet-lag-induced bad mood and brain fog. We waited an hour for a bus to take us from Incheon airport to Yongsan central station in the heart of the capital. It was 35 °C.
I’ve been here for a month. Anna has found work, starting in November; I have found the need to modify my working habits. Gone are the comfortable, temperate offices on St Giles’, replaced by an ever-changing diorama of cafés, hotel rooms and libraries. Lugging around my enormous HP Pavilion, known affectionately by some as ‘The Dominator’, proved to be unsustainable.
It’s thesis-writing time for me, so any programming I do is just tinkering and tweaking and fixing the litany of bugs that Lucy Vost has so diligently exposed. I had planned to run Ubuntu on Parallels using my MacBook Air; I discovered to my dismay that a multitude of Conda packages, including PyTorch, are not supported on Apple’s M1 chip. It has been replaced by a combination of Anna’s old Intel MacBook Pro and rewriting my codebase to install and run without a GPU – adversity is the great innovator, as the saying goes.
Continue readingTidbits from YouGov Polls
Some recent verdicts from the British public on YouGov polls
- The Queen (97%) is less well known than her husband Prince Philip (98%)
- Liz Truss’ UK popularity rating (21%) is lower than George W. Bush’s (22%)
- The most popular British dish is ‘Chips’ (84%) followed by ‘Fish and Chips’ (83%)
- Oxford (55%) is a less popular university than Cambridge (58%)
So much for Aristotle’s ‘wisdom of crowds’!
OPIG swag poll results
The results are in! 19 group members responded within 24 hours and rated 8 potential swag items on a scale from ⭐ to ⭐⭐⭐⭐⭐. Let’s see what they voted.
Overall results
First, let’s take a look at the average rating per item. People gave many stars to the coffee mug, socks, notebook, and hat.
Continue readingA logical brain teaser to derail your afternoon
Brain teasers have a strange power. For many they evoke nothing more than a mild and transient sense of curiosity. But for a certain subset of people they create an irresistible intellectual temptation which even needs to actively be avoided at times as not to completely derail conversations and take over whole afternoons.
For better or worse, I am in the camp of people who are highly susceptible to brain teasers. I just love them too much. More than once in my lifetime I had to ask a friend not to tell me about a particular brain teaser they had heard about because I knew it would inevitably take over my mind and send me down an almost hypnotic spiral of thoughts whose only escape would be finding the solution.
While brain teasers can admittedly turn into ridiculously powerful distractions for some of us, they are not necessarily a waste of time. They have high recreational value and help the mind to enter a playful and creative state. They serve as mental gymnastics to directly train logical thinking skills, and logical thinking is arguably one of the most powerful transferable skills that exists. And last but not least, brain teasers are canonically used nowadays in job interviews at some of the worlds top employers (Google, Facebook, Microsoft, prestigious hedge funds, …).
In this post, I will present one of my favourite brain teasers to see if I can get you hooked. It is a slightly modified and self-contained version of the so-called pirate game. You can find the solution at the end of the page. Enjoy responsibly! Continue readingConverting Miles to Kilometres – An inefficient but neat method
Picture this: You’re a zealous acolyte of the metric system, with a rare affliction that makes multiplying decimal numbers impossible. You’re on holiday in the UK, where road signs give distances in miles. Heathens! How can you efficiently estimate the number of kilometres without multiplying by approximately 1.60934?
Continue readingXmas proteins
For this Yuletide blog post, I sought long and hard a set of Christmas-related proteins. It is surprisingly difficult mostly because a google search for “Christmas protein” returns festive whey powders.
Continue readingLe Tour de Farce v7.0 (or: How I learned to Stop Worrying and Love the Wheels)
Come rain or shine, every summer we leave our desks and journey across Oxford’s finer drinking establishments. This year’s Le Tour de Farce was held on 11 June [1]. The trip is traditionally done by bike; however, as long as you have a helmet and lights, anything goes. To emphasise this point, Charlotte jokingly suggested rollerblades were also welcome.
Continue readingChat bots and the Turing test
When I recently tested out the voice activation features on my phone, I was extremely impressed with how well it understood not only the actual words I was saying, but also the context. The last time I used voice control features was years ago when the technology was still in its infancy. There was only a specific set of commands the voice recognition software understood and most of them were hard-coded. Given the impressive advances we have made utilizing machine learning for voice recognition and natural language processing to the point where I can tell my phone: “Hey Google, can you give me a list of the best BBQ restaurants near me?” and it will actually understand and do it, it is interesting that we still struggle with a language based technology that has been around for ages: chatbots.
Continue readingGetting home: An ordeal of flight cancellations (& what they actually cost)
Last week, a sizeable flock of OPIGlets went to ISMB in Basel. Also last week, a storm and a radar tower problem over London Gatwick (LGW) and London Heathrow (LHR) led to four of those OPIGlets being stranded in Switzerland. This is a (somewhat accurate) timeline of their ordeal:
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