With the new academic year approaching, OPIG flew off to the rural paradise of Wilderhope Manor in sunny Shropshire for their annual group getaway. The goal of this retreat was assumed to be a mixture of team building, ‘conference-esque’ academic immersion, a reconnection with nature in the British countryside, and of course, a bit of fun. It is fair to say OPIG Retreat ‘23 delivered on all accounts, leaving the OPIGlets refreshed and ready for what the next year may bring.
Recently, I’ve been using a Convolutional Neural Network (CNN), and other methods, to predict the binding affinity of antibodies from their sequence. However, nine months ago, I applied a CNN to a far more important task – distinguishing images of butter from margarine. Please check out the GitHub link below to learn moo-re.
If you are running lots of little jobs in SLURM and want to make use of free nodes that suddenly become available, it is helpful to have a way of rapidly shipping your environments that does not rely on installing conda or rebuilding the environment from scratch every time. This is useful with complex rebuilds where exported .yml files do not always work as expected, even when specifying exact versions and source locations.
In these situations a tool such a conda-pack becomes incredibly useful. Once you have perfected the house of cards that is your conda environment, you can use conda-pack to save that exact state as a tar.gz file.
This can provide you with a backup to be used when you accidentally delete conda from your system, or if you irreparable corrupt the environment and cannot roll back to the point in time when everything worked. These tar.gz files can also be copied to distant locations by the use of rsync or scp, unpacked, sourced and used without installing conda…
I don’t know if anyone out there shares this peculiar hobby of mine (God, I hope not!), but I often find myself scouring the depths of the internet for some truly bizarre academic papers. Though there is an endless supply of such content to keep one entertained (read: distract yourself during those afternoons you planned to be productive but ended up succumbing to the lunch food coma), I’ve managed to compile a short list of the most fascinating ones for your enjoyment!
The case of the disappearing teaspoons: longitudinal cohort study of the displacement of teaspoons in an Australian research institute (Lim et al, 2005, BMJ, doi: https://doi.org/10.1136/bmj.331.7531.1498)
This fantastic and robust study examines the enigmatic phenomenon of disappearing teaspoons in a shared kitchen—an issue of acute importance to all of us who rely on these tiny utensils. The authors reveal the shocking truth about teaspoons’ shockingly short half-life in research institutes. The question remains: does this phenomenon extend to other cutlery as well?
16:30 BST 27/06/2023 Oxford, UK. A large number of scientists were spotting riding bicycles across town, to the consternation of onlookers. The event was the Oxford Protein Informatics Group (OPIG) “tour de farce” 2023. A circular bike ride from the Department of Statistics, to The Up in Arms (Marston), The Trout Inn (Godstow), The Perch (Port Meadow) and The Holly Bush (Osney Island). This spurred great bystander-anxiety due to one of a multitude of factors: the impressive size of the jovial horde, the erraticism of the cycling, the deplorable maintenance of certain bikes, and the unchained bizarrerie of the overheard dialogue.
As my turn to write a blog post has fallen a few days after April 1st, I decided I would write an April Fools’ Day-inspired post and ask everyone’s favourite chatbot to tell me some jokes.
I asked ChatGPT to tell me a knock-knock joke, prompting it with various topics relevant to OPIG (including AI, antibodies, drug discovery and proteins) to see what it could come up with. I’d argue that we’re playing fast and loose with the definition of a joke (several of these just made me cringe), but here are some of the results…
One of the most treasured group meeting institutions in OPIG is snackage. Each week, one group member is asked to bring in treats for our sometimes lengthy 16:30 meeting. However, as would be the case for any group of 25 or so people, there are various dietary requirements and preferences that can make this snack-quisition a somewhat tricky process: from gluten allergies to a mild dislike of cucumber, they vary in importance, but nevertheless are all to be taken into account when the pre-meeting supermarket sweep is carried out.
So, the question on every researcher’s mind: can ChatGPT help me? Turns out, yes: I gave it a list of the group’s dietary requirements and preferences, and it gave me a handy little list of snacks I might be able to bring along…
When pushed further, it even provided me with an itemised list of the ingredients required. During this process it seemed to forget a couple of the allergies I’d mentioned earlier, but they were easy to spot; almost more worryingly, it suggested I get a beetroot and mint hummus (!) for the veggie platter:
I don’t know if I’ll actually be using many of these suggestions—judging by the chats I’ve had about the above list, I think bringing in a platter of veggies as the group meeting snack may get me physically removed from the premises—but ChatGPT has once again proven itself a handy tool for saving a few minutes of thinking!
Disclaimer – the title is a Quality Street pun only and bears no relation to the quality of the data or analysis presented below. This whole blog post is basically to discredit the personal chocolate preferences of a group member who shall remain nameless. Safe to say though, they Vostly overestimated people’s love for the Toffee Finger. Long live the Orange Creme.
Nanobodies are an exciting area of increasing interest in the biotherapeutics domain. They consist only of a heavy chain variable domain so are much smaller than conventional antibodies (about 1/10th of their mass) but despite this, manage to achieve comparable affinity for their targets, in addition to being more soluble and stable – good things come in small packages! Nanobodies are not naturally produced in humans but can be derived from camelids (VHHs) or sharks (vNARs) and then engineered to humanise them. For the rest of this blog post we will skip over the science entirely and learn how to draw a llama, a great example of a camelid species.
