We are happy to announce the release of CoV-AbDab, our database tracking all coronavirus binding antibodies and nanobodies with molecular-level metadata. The database can be searched and downloaded here: http://opig.stats.ox.ac.uk/webapps/coronavirus

CoV-AbDab already contains data on over 300 published and patented antibodies and nanobodies known to bind to at least one betacoronavirus. This database is the first consolidation of antibodies known to bind SARS-CoV-2 and other betacoronaviruses such as SARS-CoV-1 and MERS-CoV. We supply relevant metadata such as evidence of cross-neutralisation, antibody/nanobody origin, full variable domain sequence (where available) and germline assignments, epitope region, links to relevant PDB entries, and source literature. We also provide homology models for all antibodies without solved structures, to facilitate structural investigations.

Please let us know if (a) we have missed any historical studies, (b) you have data on new coronavirus binding antibodies, or (c) you would like to see additional functionality added. Email address: opig [<at>] stats.ox.ac.uk

A preprint will soon be available, detailing the contents and methods used.

We would be very grateful if you could share this resource with anyone you know studying anti-SARS-CoV-2 antibodies; we hope this database will allow them to spend more time on experiments and less time trawling through literature. Many thanks to my co-authors Aleks Kovaltsuk, Claire Marks, and Charlotte Deane for helping to build this repository from start to finish in just two weeks.