It’s been several years since I last presented a talk on prions to OPIG, so I thought a neat way of getting up to date would be to read “The prion 2018 round tables“. What’s the current understanding and are we any closer to determining a structure of PrPSc?
Continue readingMonthly Archives: September 2019
Le Tour de Farce v7.0 (or: How I learned to Stop Worrying and Love the Wheels)
Come rain or shine, every summer we leave our desks and journey across Oxford’s finer drinking establishments. This year’s Le Tour de Farce was held on 11 June [1]. The trip is traditionally done by bike; however, as long as you have a helmet and lights, anything goes. To emphasise this point, Charlotte jokingly suggested rollerblades were also welcome.
Continue readingProf. Charlotte Deane on the World Service
Prof. Charlotte Deane, the new Deputy Executive Chair of the EPSRC, Deputy Head of Division of MPLS, and Head of the Oxford Protein Informatics Group, was interviewed by BBC World Service’s programme “Tech Tent”, about the role of AI in drug discovery; jump to about 13:30 to hear Charlotte, and the segment on AI in healthcare starts at 9:45:
Handling electron density in python for fun and profit
No-one ever observed a pdb file in nature. The experimental data we build our protein models from is not quite so nicely paramterised. The vast makority of models are fit into electron density maps, mostly produced from macromolecular crystalography or cryo-em.
Continue readingWhy you should care about startups as a researcher
I was recently awarded the EIT Health Translational Fellowship, which aims to fund DPhil projects with the goal of commercializing the research and addressing the funding gap between research and seed funding. In order to win, I had to deliver a short 5 minute startup pitch in front of a panel of investors and scientific experts to convince them that my DPhil project has impact as well as commercial viability. Besides the £5000 price, the fellowship included a week-long training course on how to improve your pitch, address pain points in your business strategy etc. I found the whole experience to be incredibly rewarding and the skills I picked up very important, even as a researcher. As a summary, this is why I think you should care about the startup world as a researcher.
Continue readingChat bots and the Turing test
When I recently tested out the voice activation features on my phone, I was extremely impressed with how well it understood not only the actual words I was saying, but also the context. The last time I used voice control features was years ago when the technology was still in its infancy. There was only a specific set of commands the voice recognition software understood and most of them were hard-coded. Given the impressive advances we have made utilizing machine learning for voice recognition and natural language processing to the point where I can tell my phone: “Hey Google, can you give me a list of the best BBQ restaurants near me?” and it will actually understand and do it, it is interesting that we still struggle with a language based technology that has been around for ages: chatbots.
Continue readingSome more Python tips and tricks
There are a few useful but often underutilised Python 3 syntactic tricks that I have picked up over the last few years; I have chosen to continue in the spirit of Mark and share them here.
Continue readingA new way of eating too much
Fresh off the pages of Therapeutic Advances in Endocrinology and Metabolism comes a warning no self-respecting sweet tooth should ignore.
“Liquorice is not just a candy,” write a team of ten from Chicago. “Life-threatening complications can occur with excess use.” Hold on to your teabags. Liquorice – the Marmite of sweets – is about to become a lot more sinister.
Continue readingA Month in Basel – Summer 2019
I had an opportunity to visit Basel, Switzerland for a month between mid-July to mid-August. The first week began with the ISMB/ECCB Conference 2019, which was a 5 days event. The average temperature was 35 °C with a hottest day reaching up to 39 °C, which was rather too hot compared to a British weather. This weather was perfect to try out ‘floating’ in the Rhine river, which I missed the opportunity to, but would highly recommend it if anyone is visiting Basel in the future.
Read moreBringing practical bioinformatics to high school classrooms
Back in July a litter of OPIGlets went rooting for interesting science at ISMB/ECCB 2019 in Basel, Switzerland. When not presenting, working on my sunburn, or paying nine Francs for a beer, I made a point to attend talks outside my usual bubble of machine learning and drug discovery. In particular, I spent the latter half of the conference in the Education track, and am very glad I did. I love teaching, and am always excited to learn from more experienced educators and trainers. Today I’m going to talk about a fantastic presentation by Stevie Bain from the University of Edinburgh about introducing practical bioinformatics to high school biology classrooms through the 4273pi project.
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